Abstract

DIURETIC FOR HYPERTENSION: A REVIEW

Narayan Balasaheb Lande*, Sakharam Balasaheb Lande, Prashant Mahadev Darkunde and Mayur Sitaram Gaikwad

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Abstract

Antihypertensive drugs comprise several classes of compound with the therapeutic intention of preventing, controlling, or treating hypertension. The classes of antihypertensive drug differ both structurally and functionally. Diuretics, in one form or another, have been around for centuries and this review summarizes the key features of the most commonly used diuretics. This review and update focuses on the clinical features of Thiazide diuretics, loop diuretics and osmotic diuretics agent. Diuretics are the second most commonly prescribed class of antihypertensive medication, and thiazide-related diuretics have increased at a rate greater than that of antihypertensive medications as a whole. Compared to other classes of medications, thiazide diuretics are atleast as effective in reducing cardiovascular events (CVEs) in patients with hypertension and are more effective than b-blockers and angiotensin converting enzyme inhibitors in reducing strok Diuretics, in particular low dose thiazide and thiazide-like diuretics, are widely used in the treatment of hypertension. They have excellent outcome data and high safety and low side effects profiles. In this article, the physiology, pharmacological actions, side effects, use of diuretics in hypertension are reviewed. In addition, the effective use of diuretics in the management of hypertension is discussed.

Keywords: Thiazide diuretics, loop diuretics, potassium-sparing diuretics, hypertension, Role of diuretics.