Abstract

NATURAL GUMS AND MUCILAGES AS BIODHESIVE COMPONENTS IN ORAL CONTROLLED DRUG DELIVERY SYSTEMS: AN OVERVIEW

*Vidya Sabale¹, Vandana Patel², Archana Paranjape¹

Abstract

Bioadhesive systems provide intimate contact between a dosage form and the absorbing tissue, which may result in high concentration in a local area and hence high drug flux through the absorbing tissue. Mucoadhesion refers to the ability of material adherence to biological tissue for an extended period of time. The efficacy of oral bioadhesive drug delivery systems is affected by the biological environment and the properties of the polymer and the drug. The lower permeability of buccal region of oral cavity compared to the sublingual site is ideal for controlled-release systems. Advantages associated with buccal drug delivery have rendered this route of administration useful for a variety of drugs. This review highlights the oral mucosa, mechanism of drug permeation, and characteristics of the desired polymers, the theories behind the adhesion of bioadhesive polymers to the mucosal epithelium. The present review also highlights the studies on natural mucilages and gums in Bioadhesive controlled drug delivery systems.

Keywords: Bioadhesion, Oral mucosa, Natural Mucilage, Gums, Polymers.