Abstract

AMELIORATIVE EFFECT OF EMBLICA OFFICINALIS IN RADIATION AND CADMIUM INDUCED ALTERATION IN MICE LIVER

Bhati SL, Ranga D, Meena DC, Agarwal M, Chakrawarti A, Purohit RK*

Abstract

Background: All organisms living on earth are being perpetually exposed to some amount of radiation organizing from a variety of sources. Radiation causes deleterious effects in all forms of life due to increasing utilization and production of modern technology, a simultaneous exposure of organisms to heavy metals is also unavoidable. So there is a need of hour to search for an ideal herbal protector which reduce damaging effects induced by the both the toxicants. Objective: The present study was planned to evaluate the protective role of Emblica against combined effect of radiation and cadmium in the liver of mice. Methodology: For the present experiment, healthy male Swiss albino mice (6-8 weeks) were divided in seven groups according to treatment i.e. Cadmium chloride solution as drinking water (Group – II) or exposed to low dose 3.5 and 7.0 Gy of gamma radiation (Group – III) or combined treatment of radiation and cadmium chloride (Group - IV). The animals of experimental groups were administered Emblica extract orally seven days prior to radiation or cadmium chloride treatment (group V, VI and VII). The animals from all group were sacrificed by cervical dislocation at each post treatment intervals of 1, 2 ,4, 7, 14 and 28 days. Results: The value of total proteins, glycogen, acid and alkaline phosphatase activity increased up to day-14 in non drug treated groups and day-7 in the Emblica treated groups, thereafter value declined up to day-28 without reaching to the normal. The value of cholesterol declined up to day-14 in non drug treated groups and day-7 in the drug treated groups, thereafter value elevated up to day-28. In the above experiment the liver of Emblica treated animals exhibited less severe changes as compared to non drug treated animals at all the corresponding intervals, The combined action of Cadmium chloride and radiation showed synergistic effect. Conclusion: It is concluded that Emblica is potent enough to check radiation and cadmium induced changes in the liver of mice.

Keywords: Gamma Radiation, Cadmium chloride, Swiss albino mice, Emblica, Liver.