Abstract

DEVELOPMENT OF UV METHOD FOR POLYMORPH OF MEBENDAZOLE THROUGH PROSPECTIVE STUDY OF SOLUBILITY, IR AND XRD.

Durgesh Nandkishor Boob*, Sonali Niraj Choudhari and Sonali Ramnath Sonawane

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Abstract

The Present research work discussed for the development of simple, sensitive, rapid and economical UV Spectroscopic method development for Polymorphs of Mebendazole along with the prospective study of Infrared spectroscopy, X ray diffraction technique, and Solubility study. Solubility study from different medium was carried out. From that it is concluded that drug is to be solubilised in the 0.1 N HCL along with certain concentration of SLS. Infrared interpretation has carried out on the basis of functional group has concluded (N-H Stretching-App.3400,C=O-1730-1750,O-CH3- 2815-2850) and also decided which type of vibration is there. The XRD stud has carried out on the basis of Braggs law and qualitative phase analysis has carried out and determined the Position, d-spacing and Rel.Intensity(%). Double beam UV visible Spectrophotometer, Schimadzu, model UV 1800 with 1 cm Cuvette and test solution was prepared in the diluent methanol: water (60:40V/V) and absorption maxima shows 288 nm.

Keywords: UV Spectrophotometer, Solubility, XRD, Infrared Spectrophotometer.