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Abstract

LIPID-BASED LIPOPHILIC FORMULATIONS FOR ORAL DRUG DELIVERY

*Mr. Sunil Rambhau Sawale - B. Pharm., Dr. R. V. Shete-M.pharm. Ph. D., Dr. Vishwas C. Bhagat- M.pharm. Ph. D. and Dr. Madhuri T. Deshmukh- M.pharm. Ph. D.

Abstract

In the last decade to deliver challenging compounds such as lipophilic drugs there has been a growing interest in lipid-based formulations. This review stress the varios mechanisms of how lipid-based excipients and formulations interact with the absorption process. Using this pertinent formulation approach case studies are presented in which enhanced bioavailability was demonstrated in vivo. It is indicated that lipid-based delivery of challenging drugs requires a improvement in consecutive steps and these prepared formulation improvement is crucial for best possible provision of resources. Hence, lipid-based excipients as with respect to known biological effects, are first evaluated in view of drug solubility, phase behaviour. Mixtures can be subsequently studied in more advanced biopharmaceutical tests and are screened in simple dilution tests. Different technology are offered to encapsulate the fill in soft or hard capsules after lipid-based formulation principle is identified and also possible to formulate lipid-based systems as a solid dosage form. One has to assure that the final dosage form does not impair the biopharmaceutical potential of the lipid formulation principle, Even though such solid lipid technologies seem very attractive.

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