Abstract

PRECLINICAL EVALUATION OF ANTIDIABETIC AND HYPOLIPIDEMIC EFFECTS OF HIBISCUS TILIACEUS

Sunil Kumar*

Abstract

Objective: The study was carried out to evaluate preclinical antidiabetic and hypolipidemic effects of ethyl acetate fraction of Hibiscus tiliaceus methanolic leaves extract (HTEF) in alloxan induced diabetic rat by administering oral doses (200 and 400 mg/kg body weight). Methods: HTEF was orally for 21 days and its effect on blood glucose, lipid profile, liver profile and renal profile were examined in in normal and alloxan induced diabetic rats. Histopathological study of normal and diabetic rat organs (pancreas, liver and kidney) were also carried out after extract treatment. Results: Oral administration HTEF (200 and 400 mg/kg body weight) and glibenclamide (10 mg/kg) daily for 21 days reduced blood glucose significantly. The extract also Improved kidney, liver functions and hyperlipidaemia due to diabetes and showed favorable effect on the histopathological changes of the pancreas, liver and kidney in alloxan induced diabetes. Conclusion: The methanolic extract of H. tiliaceus reduces blood glucose level and improves lipid metabolism. The extract also shows improvement in parameters like liver profile and renal profile as well as regeneration of β- cells of pancreas in diabetic rats. Histopathological studies also show favorable effect to inhibit the histopathological changes of the pancreas and kidney in alloxan induced diabetes.

Keywords: Alloxan, Antidiabetic, Hibiscus tiliaceus, Histopathology, Hypolipidemic, Pancreas, Kidney, Liver, Rat.