Abstract

BIOCHEMICAL ANTHELMINTIC ACTION OF CARICA PAPAYA AQUOUS SEED EXTRACT IN TRICHOSTRONGYLUS COLUBRIFORMIS

Bhoopendra Kumar*, Y.P. Sahni, Nitesh Kumar

Abstract

The biochemical mechanism of anthelmintic action of aqueous extract of C. papaya seeds has been investigated on gastrointestinal parasite, Trichostrongylus colubriformis. Aqueous extract inhibited the glucose uptake and depleted the glycogen content in the presence of glucose indicating that C. papaya aqueous extract affects the energy generating mechanism of the parasite. It also significantly increased the lactate dehydrogenase enzyme suggesting inhibition of ATP production or accumulation of lactic acid. Aqueous extract of C. papaya also significantly inhibit AChE activity, In conclusion, the possible mechanism of anthelmintic action of C. papaya aqueous extract may be related to inhibition of energy metabolism as well as alteration in the AChE activity of the parasite.

Keywords: C. papaya, Acetyl cholinesterase, lactate dehydrogenase, Trichostrongylus colubriformis