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Abstract

SOLUBILITY ENHANCEMENT OF INDOMETHACIN BY FORMING SOLID DISPERSION USING MIXED HYDROTROPY

Madhur Patidar*, R.K. Maheshwari and Dr. Shikha Agrawal

Abstract

Most of the newly invented chemical drug moieties are poorly water soluble. According to BCS classification, class II and IV drugs are considered as poorly water soluble. So, enhancement of oral absorption and bioavailability of solid dosage forms remains a challenge to formulation scientists due to their solubility criteria. Therefore many techniques are being explored to enhance the solubility of poor soluble drugs. Solid dispersion is one of the most important method for enhance the solubility (dissolution rate) and hence oral bioavailability of poorly soluble drugs. In solid dispersion the particle size of drug is reduced or a crystalline pure drug is converted into amorphous form and hence the solubility is increased. Polymer incorporating in solid dispersion technology is usually hydrophilic in nature and also showing compatibility with the drug to enhance the drug solubility. This review mainly discus about solid dispersion, preparation methods, and finally characterization.

Keywords: Bioavailability, indomethacin, mixed hydrotropy, solid dispersions.


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