Abstract

ANTIBACTERIAL ACTIVITY OF 26-MEMBER [2+2] MACROCYCLES: A STRUCTURE-REACTIVITY STUDY

P. Senthilkumar, K. Radhakrishnan*, P. Karthik Manikandan

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Abstract

26 member [2+2] macrocyclic Schiff base compounds were investigated for their antibacterial activity against Gram positive and Gram negative bacteria. The recorded data of zone of inhibition showed significant broad activity when compared with standard. The structure reactivity correlation of the compounds has been studied. The antibacterial searching suggests that all the synthesized macrocyclic compounds showed moderate to very good activity against the tested organisms. Among the compounds, -COOH substituted compound showed the most promising antibacterial activity. The inhibition zone diameters of these compounds have been correlated with Hammett substituent constants, F and R parameters. From the results of statistical analysis, the effects of substituent on the antibacterial activity of compounds have been studied.

Keywords: Macrocycle, Schiff base, Cyclic imide, antibacterial activity, correlation studies.