Abstract

CARCINOMA EX PLEOMORPHIC ADENOMA

Dr. Vanishree M., Dr. Sunderesh Kamal Chander* and Dr. Sonti Sulochana

.

Abstract

Carcinoma ex pleomorphic adenoma is a malignant mixed tumor usually develops in association with benign primary or recurrent pleomorphic adenoma. They account to 5% of parotid tumors but 18% of malignant parotid tumors and have 23% recurrence rate. Clinically they may present as sudden increase in growth, pain or facial paralysis, facial tingling, trismus. It may be difficult to obtain prior history of pleomorphic adenoma but necessary for diagnosis to rule out carcinoma ex pleomorphic adenoma. Here we present a case of 60 year old female with swelling left submandibular region for 1 month. She had already underwent superficial parotidectomy left submandibular region and was diagnosed (benign) pleomorphic adenoma in histopathology. Recently on CT neck, revealed a well defined heterogenic, hypoechoic lesion of 4.5×5 cm was observed in left parotid region(Fig.1) for which she underwent revised superficial parotidectomy, which on histopathological examination revealed carcinoma ex pleomorphic adenoma (malignant). Since carcinoma ex pleomorphic adenoma is a high grade malignancy that recur locally and metastasize, it should be picked out in histopathological examination and aggressively treated at presentation.

Keywords: carcinoma ex pleomorphic adenoma, malignant oral cavity lesion, superficial parotidectomy and immunohistochemistry markers.