Abstract

SYNTHESIS, SPECTRAL AND MICROBIOLOGICAL EVOLUTION OF 3-CHLORO-4-[1-N-PHENYL-3-PHENYL-PYRAZOLE]-1-N-ARYL-AZETIDIN-2-ONE DERIVATIVES

K. V. Goswami*, Kokila A. Parmar and Sarju N. Parajapati

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Abstract

The present work of 3 - chloro-4-[1-N-phenyl-3-phenyl-pyrazole]-1-Naryl- azetidin-2-one derivatives have been synthesized by the reaction of Schiff bases formation of 1-N-phenyl-3-phenyl-4-formyl pyrazole (PFP) (2a-h) and Arylidine-[1-N-phenyl-3-phenyl-pyrazole] (3a-h) gives (4a-h) 3-chloro-4-[1-N-phenyl-3-phenyl-pyrazole]-1-N-(3,4- diethoxyphenyl)-azetidin-2-one derivatives. The structure of synthesized compounds elucidate by spectroscopic methods like IR, 1HNMR, Mass and elemental analysis. The efficient novel product (4ah) with different active substituent was screened against antimicrobial activity and it showed notable efficacy against tested microbes.

Keywords: Phenyl-pyrazole, azetidin-2-one derivatives, Arylidine, antimicrobial activity.