Abstract

TO EVALUATE THE ANTI-INFLAMMATORY ACTIVITY OF RHIZOMES EXTRACT OF ALPINIA GALANGA

Purnendra Kumar Gupta*, Dr. Jagdish Chandra Rathi and Manish Sahu

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Abstract

Percentage yield of petrolium ether and ethanolic extract of Alpinia galanga exhibited in 1.53 and 3.46 % respectively. The phytochemical screening revealed the presence of flavonoids, phenol, carbohydrates, tannins, Proteins and saponins compounds in the Alpinia galanga extract. Total phenolic content 0.856 (mg GAE/100mg) and total flavonoid content 0.942 (mg QE/100mg). Ethanolic extract of Alpinia galanga possess significant antiinflammatory potential. Ethanolic extract of Alpinia galanga rhizome possess significant antiinflammatory potential. Ethanolic extract of Alpinia galanga rhizome prevented formalin-induced paw edema in a dose- dependent manner showing significant anti-inflammatory effect, percentage inhibition shown was found to be 69.17% and 72.27% at dose of 100 and 200 mg/kg, respectively. Hence, it is suggested that ethanolic extract of Alpinia galanga rhizome may provide benefits in the management of inflammation. These findings support the use of the extract in traditional system of medicine for the management of inflammatory conditions. These results clearly prove the anti-inflammatory effects of ethanolic extract of Alpinia galanga rhizome in experimental animals and support the potential usage of this plant in the management of inflammatory diseases.

Keywords: Anti-inflammatory, Alpinia galanga, Phytochemical, NSAIDS.