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Abstract

FORMULATION AND EVALUATION OF NIOSOMAL GEL OF GATIFLOXACIN

Anjali Dangi*, Anwar Iqbal Khan and Dr. Navjot Singh

Abstract

The objective of the work was to formulate niosomes of a drug meant for infections caused due to Gram-positive and Gram-negative bacteria. Gatifloxacin sesquihydrate was white crystalline odorless powder. When tested for its solubility in various solvents, it was determined that drug sample was slightly soluble in water and 0.1 HCl, soluble in methanol, ethanol and Buffer 7.4 pH etc. melting point observed 182-185°C. Gatifloxacin sesquihydrate solution was scanned in the U.V. range of 200-400 nm. The spectrophotometric method of analysis of Gatifloxacin at max 292 nm was found. The standard curves were prepared in Methanol at max 292 nm. The data were regressed to obtain the straight line. The correlation coefficient was 0.996 while the concentration range of 2-10 g/ml. Partition coefficient value of Gatifloxacin was 2.54 revealed its Lipophilic nature. The IR spectrum of drug substance was authenticated using IR spectroscopy. Niosomes were prepared by the thin-film hydration method. Gatifloxacin loaded niosomal dispersion was offwhite in color and fluid in nature. It was stable and did not show sedimentation. pH was found to be in the range of 5.1-6.8. Vesicle size found 1.42 to 2.13μm, Percentage drug content found 91.26 to 99.14% and viscosity was 2.255 to 3.333. The values of zeta (ζ) potential of the drug loaded niosomal formulation were in the range of-20.29 to -27.77mV. Formulations F5 and F6 had 90.21 and 95.25% of drug release respectively. It can be concluded that for better stability, the formulations should be stored at low temperature in refrigerator.

Keywords: Gatifloxacin sesquihydrate, Niosomes, gel, Evaluation.


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