Abstract

THYMOMA B2 TYPE WITH MYASTHENIA GRAVIS - A RARE CASE REPORT

Dr. Sunderesh Kamal Chander U., Dr. Vani Shree M.*, Dr. Muthuvel E. and Dr. Sonti Sulochana

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Abstract

Thymoma is a unique thymic epithelial neoplasm with indolent growth and rarely presents with local invasiveness and metastases. Thymomas have been reported to be associated with various parathymic syndromes, most commonly such as myasthenia gravis and pure red cell aplasia. Myasthenia Gravis is a disorder of abnormal neuromuscular transmission and is associated with thymoma about 20 - 25% of the cases. Here we presented 24 yr old female with a 4 months history of intermittent left-sided pleuritic-type chest pain and wheezing. She was a known case of Myasthenia gravis for past 2 yrs, under medication. On CT scan, chest shows multiple well defined isodense pleura based mass like to lesion of varying size involving the coastal diaphragmatic and mediastinal pleura surface of left lung with board base towards pleura with calcification, diagnosed to be neoplastic mesothelioma. Later on histopathological examination tissue showed predominantly lymphocytes and multiple foci composed of pale elongated cells having moderate eosinophilic cytoplasm in sheets with no evidence of necrosis/increased mitotic activity and finally we concluded as Thymoma- Type B2. This case was reported due to its rarity.

Keywords: Thymoma, B2 type, Myasthenia gravis, Mesothelioma neoplasm.