Abstract

EFFECT OF ALLIUM SATIVUM AND ALOE BARBADENSIS ON INDOMETHACIN INDUCED STOMACH ULCER IN MALE WISTAR RATS

Obiesie Ifechukwu Justicia, Obinwa Benedict Nzube*, Ogbuokiri Doris Kasarachi, Okubike Emeka, Mmoto Onyinye and Onyedibe, Lilian Ukamaka

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Abstract

Natural compounds derived from plants materials have been used in the treatment of gastric ulcers for centuries because of their low side effects as well as significant medicinal effects. In this study, the effect of Allium sativum and Aloe barbadensis rind extracts on indomethacin induced stomach ulcer in male albino Wistar rats was evaluated. A total of 35 rats divided into seven (7) groups of five (5) animals each were used in this study. Group A received only water and feed, while the other groups received: Group B 30mg/kg of indomethacin only, Group C 200mg/kg of Aloe barbadensis rind extract, Group D 200mg/kg of Allium sativum, Group E 30mg/kg of indomethacin + 200mg/kg of Allium sativum, Group F 30mg/kg of indomethacin + 200mg/kg of Aloe barbadensis rind extract, Group G 30mg/kg of indomethacin + 200mg/kg Allium sativum + 200mg/kg Aloe barbadensis rind extract. Administration lasted for seven days only after which they were sacrificed and the stomach harvested for histopathological studies. Data were subjected to ANOVA followed by post hoc LSD and significant at p

Keywords: Allium sativum, Aloe barbadensis, indomethacin, stomach ulcer.