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Abstract

THE QUANTITATIVE DETERMINATION OF THE ASPIRIN CONTENT OF TABLETS USING UV AND VISIBLE WAVE LENGTH SPECTROSCOPY

Ravindra Khadak*, Rekha Birle, Dr. Nandu Kayande, Dr. Pankaj Kushwah

Abstract

The quantitative determination of aspirin method was developed using UV-Vis spectrophotometer for estimation of aspirin pure and aspirin tablet from tablet formulation by percent purity. Two analytical wavelength ranges used were i.e. 302-330nm and 530-550. Aspirin (acetylsalicylic acid) is an important drug used for its analgesic, antipyretic and anti-inflammatory properties. Various analytical techniques such as HPLC, Mass spectroscopy etc are available for the determination of aspirin content in drugs but these methods are expensive and laborious in nature. Therefore, these methods are neither suitable nor accessible for undergraduate students. In this background, we have used a very simple analytical technique to teach students how to determine aspirin contents in various drugs. Using this method the students have successfully determined the aspirin content in commercially available drugs like ASA, Aspesol, Colsprin, Ecosprin and Disprin. The results obtained in the present study were found comparable to data reported elsewhere. Therefore, this study can be used by other research and/or educational institutes to train undergraduate students in drug assay. he aspirin content of commercial tablets is routinely determined using the acid/base titration method described in the British Pharmacopoeia but a large number of alternative instrumental methods are also described in literature. This application note will compare two such spectrophotometric methods. After acidification the resulting salicylic acid can be determined directly from its absorption maxima at 302nm (Method 1) or it can be derivatives with Fe(III) to produce a violet coloured complex that can be quantified at its absorption maxima of 530nm (Method 2).

Keywords: aspirin, salicylic acid, ecospirin, methanol, ferrous chloride.


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