Abstract

METAPLASTIC CARCINOMA OF BREAST A RARE ENTITY- TWO CASE REPORTS

Vanishree M., Sunderesh Kamal Chander*, Sonti Sulochana and Dr. Dhanya Menon

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Abstract

Metaplastic carcinoma of breast is a rare entity, representing about 0.2 to 5% of invasive carcinomas of breast, usually of poor prognosis with a disease free survival rate being 78.1%. In the present study, we report two cases of metaplastic carcinoma breast, one revealing mesenchymal differentiation-chondroid and osseous differentiation and other revealing mixed epithelial and mesenchymal type showing squamous and pleomorphic spindle cell sarcomatous elements. Both were estrogen receptor, progesterone receptor and Her2neu negative on immunohistochemistry. Early diagnosis of metaplastic carcinomas is of exceeding importance due to the difference in the therapeutic regime and its poor prognosis. Metaplastic carcinomas express HER1/epidermal growth factor receptor (EGFR), and treatment with EGFR inhibitors is effective in few studies.

Keywords: Metaplastic, Breast, Carcinoma, Triple negative, EGFR, EGFR inhibitor.