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Abstract

TOPICAL SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEM: A NOVEL APPROACH FOR TOPICAL DELIVERY OF DRUG

Banita*, Sobhna Thakur and Reena

Abstract

Topical or dermal drug delivery system is the approach of delivering the drug onto the skin for protection of skin or for local and systemic effect. Dermal delivery system is although a conventional method but research is still continuing to find its applicability in various aspects of latest pharmaceutical investigations as delivery system. Skin is a multilayered structure that is easily accessible organ for drug delivery and has the potential of delivering drugs with better efficacy and overcoming the disadvantages associated with other routes of drug delivery. SMEDDS traditionally originated as oral lipid based systems with the purpose of delivering lipophilic drugs. However, new approaches are presented by utilising this simplified system of drug delivery. Although routes such as topical, rectal, nasal and vaginal have gained lesser attention but the delivery of drug containing SMEDDS topically is noteworthy. Topical SMEDDS has the potential of delivering lipophilic drug with high efficacy topically in a cost effective manner. This article reviews the topical drug delivery system, self-microemulsifying drug delivery system and the concept of topical SMEDDS with their potential advantages in pharmaceutical industries. An overview of reviews was conducted to locate published literature between 2000 and 2020.

Keywords: Dermal drug delivery, SMEDDS, Lipophilic drugs, Topical delivery, Prolonged release, Effective delivery.


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