Abstract

A REVIEW: GASTRO RETENTIVE DRUG DELIVERY SYSTEM

*Suresh Choudhary, Santosh Waghmare and Hemant Kamble

.

Abstract

The goal of this review on gastroretentive drug delivery systems (GRDDS) was to compile the current literature with a focus on a few gastroretentive approaches that have recently emerged as important methodologies in the field of site-specific orally administered sustained/controlled release drug delivery. To overcome physiological challenges such as short gastric residence times (GRT) and unpredictable gastric emptying times, technological efforts have been made in the study and development of rate-controlled oral drug delivery systems (GET). GRDDS is a method for extending the GRT and targeting site-specific drug release in the upper gastrointestinal tract (GIT) for a local or systemic effect. Because of the fast gastric transition from the stomach, conventional oral dose forms have low bioavailability issues, especially for medications that are less soluble at an alkaline pH of the intestine. Additionally, medications that have a local action in the stomach are quickly emptied and do not spend enough time in the stomach. To lower the frequency of dose administration, several efforts have been made to extend the retention duration of drug delivery systems. GRDFs not only extend dosing intervals, but they also improve patient compliance beyond what is currently possible with controlled release dosage forms. The benefits, drawbacks, and characterisation of gastroretentive drug delivery devices are discussed in this article. This study contains patents and commercially marketed gastroretentive products.

Keywords: Gastroretentive drug delivery system; approach; floating system; Evaluation.