Abstract

A REVIEW ON INCLUSION COMPLEXES FORMULATION AND CHARACTERISATION

Vijaya Padwal*, Sachin Kothawade, Mansi Gardare, Santosh Waghmare and Dr. Hemant Kamble

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Abstract

Solid dispersions are one of the most promising strategies to improve the oral bioavailability of poorly water-soluble drugs. By reducing drug particle size to the absolute minimum, and hence improving drug wettability, bioavailability may be significantly improved. Poorly water-soluble compounds have solubility and dissolution related bioavailability problems. The present review deals in detail about solid dispersion technology and its manufacturing techniques at laboratory and industrial level. Solid dispersion techniques have attracted considerable interest of improving the dissolution rate of highly lipophilic drugs thereby improving their bioavailability by reducing drug particle size, improving wettability and forming amorphous particles. This article reviews historical background of solid dispersion technology, limitations, classification, and various preparation techniques likes Inclusion complexation with cyclodextrins, Size reduction technology, Functional polymer technology and Solid dispersions etc. with its advantages and disadvantages. This review also discusses the recent advances in the field of solid dispersion technology.

Keywords: Inclusion, Dispersion, Complex, Solubility, Polymers.