Abstract

A REVIEW ON IN-SITU GELLING FOR OCULAR DRUG DELIVERY SYSTEM

Harshitha V. Y.* and Somashekhar C. N.

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Abstract

The ophthalmic drug delivery system is fascinating and challenging due to the typical physiologically factor of the eyes, which reduces the bioavailability of ocular products. The development of new ophthalmic dosage forms for existing drugs to improve efficacy and bioavailability, patient compliance and convenience has become one of the primary trends in the pharmaceuticals industry. The present review encompasses various conventional and novel ocular drug delivery systems, preparation methods, characterization and recent research in this area. In situ, gelling systems are polymeric formulations in sol forms before entering the body but change to gel forms under physiological conditions. The sol-gel transition depends on one or a combination of different stimuli, like pH change, temperature modulation, solvent exchange, ultraviolet irradiation and the presence of specific ions or molecules. Drug delivery systems having such properties can be widely used for sustained delivery vehicle preparation of the bioactive molecules. Some crucial advantages of these systems are ease of application, reduced administration frequency, and protection of the drug from environmental condition changes.

Keywords: In – situ ocular gel, Temperature dependent system, pH trigerring in situ gelling system, Ion activated in situ gelation, etc.