Abstract

BIOACTIVE COMPOUNDS INTEGRATED WITH POLYMERIC NANOCAPSULES USED FOR CANCER TREATMENT

*Jyoti Adate, Bhairavi Suryavanshi and Annika Durve Gupta

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Abstract

Nanocapsules are nanostructures consisting either liquid or solid core with a polymeric shell. There is an emerging interest in the usage of nanocapsule for various drug delivery applications. In this review, various types of nanocapsules used in delivery systems as well as their use for cancer thernostics have been studied along with nanocapsule formulation, characterizations and applications. Incorporation of phytochemicals which possesses anticancer properties including vitamins, antioxidant phenolic, dietary fiber, flavonoids, and polyphenols becomes convenient due to encapsulation methods. Nanocapsules has been synthesized by using polymers as outer shell materials to protect internally filled bioactive compounds against external factors such as light, heat and oxygen which will increase the stability and improve the bioavailability of the nanoencapsulated compounds. Furthermore, the challenges faced due to conventional cancer therapy are reviewed and how nanocapsule can overcome them are studied. The progress in nanotechnology has favoured the development of various encapsulation methods which will regulate the pharmacological and biopharmaceutical properties of drugs and also provide favourable conditions to the encapsulated drug. The size, shape, charge and pattern of nanocapsule (nano therapeutic molecules) are parameters that need to be investigated in order to promote and optimize cell and tissue interaction. The nano encapsulation of antitumor active compounds is a promising approach to improve the efficacy of various tumour treatments. In this review different methods which are used to synthesize various nanocapsule are discussed and their applications for the treatment of several diseases are discussed by using examples from the literature.

Keywords: Nanocapsule, encapsulation, bioactive compound, polyphenol, polymeric nanocapsule, cancer.