Abstract

TO EVALUATE THE ANTI-PSORIATIC ACTIVITY OF SOME MEDICINAL PLANTS: AN IN-SILICO APPROACH

*Lokendra Singh Rathor and Vishal Mathur

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Abstract

Psoriasis is a common and chronic autoimmune skin disease that affect 2-3% of population worldwide. Psoriasis not only affect skin but also other organ systems viz. gastro-intestinal tract, musculoskeletal system, and eye. It is illustrated by increased proliferative keratinocyte that multiply up to 10 times more rapidly than normal cells and causes dilation of cuticular capillaries. The current treatments available are topical, light therapy and systemic medications but the limitation is that these have side effects and is a long therapy. Many herbal plants are reported which can be used in the treatment of the Psoriasis. In this study we have selected the phytoconstituents and these were docked with the JAK protein. It was observed that Lupeol, Hypericin, Luteolin and Rigidin had good binding affinities with target molecule to inhibit the inflammatory mediators (IL-17, IL-23, IL-9, IL-28, IL-6, TNF-α etc.) activated due to activation of JAKs. The plants studied in the present work showed better affinity to bind with JAK, hence, we propose that the above mentioned phytoconstituents can be used for the treatment of psoriasis.

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