Abstract

COMPARITIVE IN-VITRO DISSOLUTION AND PHYSICAL PARAMETER STUDY OF VARIOUS MARKETED PREPARATION OF IBUPROFEN TABLETS

Ravi D. Hole* and Nayna V. Khedekar

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Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) have fewer regulatory restrictions, but they too have important adverse effects which are more likely at higher dose or with longer courses. NSAIDS are a group of unrelated organic acids that mostly affect gastrointestinal tract (GIT). Dyspeptic complaints, upper GI bleeding, and mucosal and duodenal ulcers, are common adverse drug reaction associated with this group and may be life threatening. Three different marketed brands of ibuprofen tablets were selected and purchased from a local retail pharmacy (India). All tests were performed within product expiration dates during study period. The compendial standards are weigh Variation, drug content, disintegration time, and dissolution, whereas hardness and friability also been check the result is shown in table no. 21.The uniformity of weight determination for three codes of ibuprofen tablets gave values that are within limits. There was different mean weight of all brands because of different excipient used in the different brands

Keywords: NSAIDS, Ibuprofen tablets, dissolution, marketed preparation.