Abstract

LODHRADI KASHAYA AS A POTENT ANTIDIABETIC AGENT: A DRUG REVIEW

Nihar Ranjan Mahanta*, Preetimayee Sahoo and Mridula

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Abstract

Lodhradi Kashaya is a herbal preparation described in Vasavarajeeyam containing four components Lodhra, Musta, Haritaki and Katphala given in decoction form which should to be prepared daily and given to Madhumeha or diabetic patients due to its antihyperglycemic actions. Various experimental studies on animals and humans reveal the anti-diabetic, antioxidant, hepatoprotective and renoprotective properties of Lodhra, Musta, Haritaki and Katphala individually and also in combination. Studies show that it acts by stimulating the beta cells of the pancreas and increasing sensitivity of the peripheral tissue to insulin thus enhancing glucose utilisation. The pharmacodynamics analysis show that there is predominance of Kashaya (100%), Tikta and Katu Rasa (75%); Laghu (100%), Ruksha (75%) and Tikshna (25%) Guna; Anushna Virya and Katu Vipaka (75%). 100% of the components are Kapha Shamaka, 75% are Pitta Shamaka and 50% are Vata Shamaka, hence it can be said that Lodhradi Kashaya is Tridosha Shamakaa predominantly Kapha Shamaka. Most of the drugs are having Kapha-medahara property which ultimately corrects the vitiated Slesma, Meda and Mamsa dhatu. Hence effective in controlling Madhumeha. Thus, Lodhradi Kashaya can be used as a potent anti diabetic agent.

Keywords: Lodhradi Kashaya, Pharmacodynamics analysis, Anti-diabetic actions, Evidences.