Abstract

IN VITRO STUDIES AND EVALUATION OF TELMISARTAN MARKETED TABLETS

Snehal Jadhav*, Prachi Lokhande, Vaibhav Narwade, Mahananda Ghodke, Rutuja Desai and Prerna Mote

.

Abstract

In this research project, we are assigned a topic to study on the in vitroequivalency evaluation of Telmisartan tablets. The main focus of this research is to conduct dissolution test on the tablets to determine the compliance with a given official monograph. Dissolution testing is a method for evaluating physiological availability that depends upon having the drug in a dissolved state. In vitro dissolution test is conducted on four different brands of Telmisartan tablets to evaluate their equivalency. Tablets or capsules taken orally remain one of the most effective means of treatment available. The effectiveness of such dosage forms relies on the drug dissolving in the fluids of the gastrointestinal tract prior to absorption into the systemic circulation. The rate of dissolution of the tablet or capsule is therefore crucial. In this research, our aim is to develop an in vitrotest method that fully models the physiological conditions in the GI tract. The dissolution media used closely resembles the GI fluid in the stomach. Simulation of GI pH gradients, peristaltic movement, transit times, biliary and pancreatic secretions and water absorption are examples of features in such dynamic in vitro test model.

Keywords: In-vitro, Telmisartan, Comparative Dissolution Profile.