Abstract

CHEMOSENSITIZERS IN CANCER THERAPY: A REVIEW

Sruthy Jacob I.*, Rakhi AR, Juno S., Shahina N. S. and Anjana A. K.

Abstract

Chemosensitizers, from the name we know that Chemo means chemical and Sensitizer means agent which has a capability to sense the condition or oppose the presence of some agent by any reaction. Chemosensitization is an activity in which a given scheme with one drug is used to enhance the activity of another selectively in the tumor cells, and also limit any undesired toxicity or side effects in normal cells. The strategy to use this chemosensitizers are, it has the ability to overcome the chemoresistance. The huddle in cancer therapy is time dependent tumour resistance to therapy (chemoresistance) and nonspecific toxicity toward normal cells. This huddle in chemotherapy is the chemoresistance. In conventional chemotherapy, chemoresistance will arise after a short term, so that the dosage efficacy will be affected. While using chemotherapy with a chemosensitizer, reduce the dosage and also side effect.

Keywords: Chemosensitizers, Chemoresistance, Cancer, Efficacy, Toxicity.