SYNTHETIC APPROACHES OF IMIDAZOTHIAZOLE SCAFFOLDS: AN UPDATED REVIEW
Senthil Kumar R.*, Praveen S., Shridharshini K., Maruthamuthu M., Mohanapriya K., Anjana E.
Abstract
Fused heterocyclic compounds are one of the most important systems
in medicinal chemistry because of their extensive biological activity.
The imidazothiazole, which has a bridgehead nitrogen atom, is
particularly important because of its several applications, including
anticancer, antimalarial and antiviral. Due to its numerous biological
applications, designing diverse imidazothiazole scaffolds has grown
more relevant. The present review paper discusses the various
synthetic techniques for imidazothiazoles and their derivatives. The
review would be useful in future drug design for the development of
more promising drug-like scaffolds.
Keywords: Cyclization, Fused heterocyclic ring system, Imidazothiazoles, Multicomponent reaction, One pot condensation, Claisen-Schmidt condensation.
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