Abstract

SYNTHETIC APPROACHES OF IMIDAZOTHIAZOLE SCAFFOLDS: AN UPDATED REVIEW

Senthil Kumar R.*, Praveen S., Shridharshini K., Maruthamuthu M., Mohanapriya K., Anjana E.

Abstract

Fused heterocyclic compounds are one of the most important systems in medicinal chemistry because of their extensive biological activity. The imidazothiazole, which has a bridgehead nitrogen atom, is particularly important because of its several applications, including anticancer, antimalarial and antiviral. Due to its numerous biological applications, designing diverse imidazothiazole scaffolds has grown more relevant. The present review paper discusses the various synthetic techniques for imidazothiazoles and their derivatives. The review would be useful in future drug design for the development of more promising drug-like scaffolds.

Keywords: Cyclization, Fused heterocyclic ring system, Imidazothiazoles, Multicomponent reaction, One pot condensation, Claisen-Schmidt condensation.