Abstract

THE EFFECT OF NUTRITIONAL SUPPLEMENTATION WITH CURCUMIN ON ALKALINE PHOSPHATASE LEVELS IN GINGIVAL CREVICULAR FLUID OF CHRONIC PERIODONTITIS AND CHRONIC PERIODONTITIS PATIENTS WITH RHEUMATOID ARTHRITIS: A RANDOMIZED CONTROLLED TRIAL.

Dr. Manjunath S. M., Dr. Krishna Kripal*, Dr. Lekshmi R., Dr. S. Savita, Dr. Shanmugapriya P. A., Dr. R. S. Senthil Rajan, Dr. Blaina Carol D’souza

Abstract

Background And Objectives: As periodontitis is an infectious and polymicrobial disease, bony variations are crucial as their destruction is in control of tooth loss. A key system for controlling bone turnover is the alkaline phosphatase level (ALP) level. As an attempt to assess the effect of curcumin on ALP levels in chronic periodontitis patients and chronic periodontitis patients with rheumatoid arthritis (RA), this study was done to evaluate the effect of nutritional supplementation with curcumin on ALP level in gingival crevicular fluid of chronic periodontitis patients. Methodology: A randomized controlled clinical trial was conducted for a total of 78 patients diagnosed with chronic periodontitis and reported to the Department of Periodontology, Rajarajeswari dental college and hospital, Bangalore and are allocated into Group I – 20 patients with chronic periodontitis underwent scaling and root planing and were prescribed with curcumin supplements in the form of tablets(500mg) twice daily for 6 weeks. Each tablet contains 95% curcuminoid. Group II – 20 patients with chronic periodontitis underwent scaling and root planing and were prescribed with placebo tablets twice daily for 6 weeks. Placebo tablet consist of starch containing gelatin capsule. Group III – 20 patients with chronic periodontitis and rheumatoid arthritis underwent scaling and root planing and were prescribed with curcumin supplements in the form of tablets (500mg) twice daily for 6 weeks. Group IV- 20 patients with chronic periodontitis and rheumatoid arthritis underwent scaling and root planing and were prescribed with placebo tablets twice a day for 6 weeks. In all the groups the clinical parameters like GI, PI, PD, CAL were recorded and GCF was collected from all the subjects at baseline and at 6 weeks after treatment to estimate the levels of ALP by Enzyme linked Immunosorbent Assay (ELISA). Results: In group I and group III there was a significant decrease in GI, PI, PD, CAL from baseline to 6 weeks. In all the groups there was a decrease in the ALP level from baseline to 6 weeks after treatment but the decrease in group I and group III was more statistically significant. Conclusion: Nutritional supplementation with curcumin showed significant decrease in clinical parameters and also ALP level at 6 weeks after treatment in both chronic periodontitis patients and chronic periodontitis patients with rheumatoid arthritis. Hence curcumin can be effectively used as an adjunct in the treatment of periodontal diseases.

Keywords: Curcumin, ELISA, GCF, Periodontitis, ALP level, Rheumatoid Arthritis.