Abstract

SNEDDON – WILKINSON DISEASE A.K.A SUBCORNEAL PUSTULAR DERMATOSIS – A RARE STERILE PUSTULAR ERUPTION OF SKIN

Sunderesh Kamal Chander U., Rajeswar K.*, Krishna Priya R. and Vimal Chander

Abstract

Subcorneal Pustular Dermatosis (SPD) is a rare, chronic, relapsing, sterile pustular eruption characterized by pea sized pustules. Histopathologically characterized by subcorneal pustule filled with neutrophils. The exact pathogenesis of Subcorneal pustular dermatosis is unknown but recent studies showed it is due to squamous intercellular substance IgA leads to neutrophilic infiltration. Elevated levels of tumor necrosis factors in the serum and pustules may be responsible for neutrophil activation. We reported a case of 27 yr old female from dermatology department of a tertiary care center, complaining of pus filled lesions all over the body with fever, burning sensation and itching since nine days. On clinical examination multiple pustules coalescing to form plaques over erythematous base noted over the face, neck, B/L upper limbs, chest, abdomen, back, bilateral thighs and clinical diagnosed as pustular psoriasis. Later, skin biopsy was performed. On histopathological examination revealed a final diagnosis as subcorneal pustular dermatosis. We presented this case report due to its rarity.

Keywords: Sneddon Wilkinson disease, subcorneal pustular dermatosis, Hypopyon sign, Pustular psoriasis and benign dermal lesions.