Abstract

EVALUATION OF ADVERSE DRUG REACTIONS ASSOCIATED WITH THE ANTI PSYCHOTROPIC DRUGS IN THE MANAGEMENT OF PATIENTS WITH BIPOLAR AFFECTIVE DISORDER AND SCHIZOPHRENIA PATIENTS

Goluguri Lavanya*, Manepally Ramya Krishna, Meesala Padmavathi Priya, Mopuri Preethi Ram babu Bathini

Abstract

Background: Adverse drug reactions ADRs are the frequent drugrelated concern all over the world. Psychotropic medications are widely accessible, and their use is always being on the rise. Adverse drug reactions (ADRs) to psychotropic agents are common and may direct to noncompliance or even termination of therapy As a result, monitoring, evaluating, preventing lowers the risk of developing ADRs thereby reducing healthcare costs. Methodology: A prospective observational study was conducted in the inpatient & outpatient unit of the psychiatry department of RVM institute, Laxmakkapally for 6 months. Out of 123 patients, 191 ADRS were identified in 58 patients. Results and Conclusion: The most commonly identified ADRS are tremors (21.5%), weight gain (19.4%), xerostomia(11%), giddiness (6.8%), sedation (5.8%), fatigue (4.7%), headache (4.2%), blurred vision (3.7%), EPS (3.1%), hypersomnia (2.6%), constipation (2.6%). According to Naranjo's scale, majority of ADRS fall under the criteria probable(50%), possible (43.9%), definite (4.1%), unlikely (2%). Probability assessment by WHO-UMC probability scale shows 53.4% of ADRs are probable and predictability is showing as 66.49% .Preventability assessment by Modified Schumock and Thornton’s Scale shows that 43.98% of ADRs are not preventable. According to T-test and CHI Square test Values of ADR's and Drugs per prescription are statistically significant, p=

Keywords: Bipolar Affective Disorder schizophrenia, psychotropic drugs, adverse drug reactions.