Abstract

EVALUA TION OF ANTI-ASTHAMATIC ACTIVITY OF IPOMEA AQUATICA FORSK ON EXPERIMETAL ANIMALS

*Dr. DV. Kishore, Qamar Naseem, Dr. Shaik Mohd Khasim, Dr. Sridhar Baburao

Abstract

Background: Asthma is a complicated condition marked by diverse and recurrent manifestations such as airway restriction, bronchial hyperresponsiveness, and underlying inflammation. The current study was done to evaluate the antiasthmatic activity of methanolic extract of Ipomoea aquatica (MEIA) in experimental rats and guinea pigs. Methodology: Induction of edema in right hind paw of rat was brought about by subcutaneous injection of 0.1 ml of 1% carrageenan into the planter region. By treating with histamine aerosol using an ultra-sound nebulizer, bronchial asthma was experimentally induced in guinea pigs. Results: MEIA showed a dose dependent significant inhibition of paw edema following carrageenan administration (low dose - p < 0.01, high dose – p < 0.001). MEIA also exhibited cosiderable (ap < 0.001) percent reduced contraction at 100 μg/ml on isolated ileum of Guinea pig. Conclusion: It can be concluded that MEIA possesses significant concentration-dependent antiasthmatic activity. It also brought about the inhibition of contraction caused by histamine, confirming its bronchodilator activity.

Keywords: Asthma, Ipomoea aquatica, Methanolic extract, Antiasthmatic activity, Guinea pig and Histamine.