Abstract

DEVELOPMENT AND EVALUATION OF DRDAS OF COMBINATION OF DIGOXIN AND PHENYTOIN SODIUM FOR CONGESTIVE HEART FAILURE

P. U. Parikh*, V. A. Pande, P. S. Kudi, S. R. Yadav and V. P. Patel

Abstract

Background & Objective: The purpose of this research was to develop a Dual Release Drug Absorption System (DRDAS) that would increase the therapeutic efficacy of digoxin for the treatment of congestive heart failure while reducing side effects. To treat Congestive Heart Failure and digoxin side effects, bilayer tablets comprising a combination of two different cardiovascular drugs i.e., digoxin and phenytoin sodium were used. Method: In bilayer tablets various superdisintegrants added, digoxin is utilized as an immediaterelease layer, and phenytoin sodium is used as a prolonged-release layer with addition HPMC K100M. The optimization method was used to test bilayer tablets for immediate release Digoxin layer and sustained release Phenytoin Sodium bilayer. Result: Digoxin's immediate release layer demonstrated complete release in 20 minutes, while phenytoin sodium release was prolonged to 6-8 hours. Conclusion: according to the results of this study, Digoxin and phenytoin sodium bilayer pills were successfully prepared for the treatment of congestive heart failure and digoxin side effects (Arrhythmic condition).

Keywords: Congestive Heart Failure, Dual Release Drug Absorption System (DRDAS), Digoxin, Phenytoin sodium, HPMC K 100M.