Abstract

DESIGN, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF SOME NOVEL SUBSTITUTED 1,5-BENZOTHIAZEPINE DERIVATIVES

Kumara Prasad S. A.*, Chethan S. H., Shabaraya A. R.

Abstract

A new series of 1,5-benzothiazepine derivatives were synthesised from various chalcones of 2-acetylpyrazine. Chalcones were prepared by the reaction of 2-acetylpyrazine with various aromatic and heteroaromatic aldehydes in the presence of ethanol and 40% NaOH followed by acidification with Hydrochloric acid. These chalcones were refluxed with 2-aminothiophenol in the presence of methanol and piperidine to get 1,5-benzothiazepine derivatives. Finally, the structures of all the various synthesized compounds were confirmed on the basis of IR and 1H NMR spectral data and these compounds were screened for their antimicrobial activity.

Keywords: Chalcones, Aromatic aldehydes, Benzothiazepines, Antimicrobial activity.