Abstract

FORMULATION AND EVALUATION OF CHITOSAN NANOPARTICLES OF METFORMIN IN NANO DRUG DELIVERY SYSTEM

Sunil Singh*, Brajesh Ku Arjariya, Sheenam Mansuri, Mohd Jalaluddin and Rahim Khan

Abstract

Diabetes is one of the leading causes of morbidity and mortality due to specific microangiopathy and macroangiopathy. Diabetes insipidus (DI) is a condition characterized by excessive thirst and excretion of large amounts of severely diluted urine, with reduction of fluid intake having no effect on the concentration of the urine. Selected Drug is Metformin for the study. A small quantity of powder was placed into a fusion tube. The solubility was observed only by visual inspection. Phases were separated in a separating funnel and the aqueous phase was analysed for amount of drug after appropriate dilution by UV spectrophotometer. The pellets obtained were resuspended in deionized water by sonication, then centrifuged and dried at room temperature. The different formulations of Metformin nanoparticles were obtained. Metformin with the help of nano-delivery systems could have potentially reduce side effects. Nanotechnology is a very active research area in both academic and industrial settings. Hence, an attempt was made to formulate the nanoparticles anti-diabetic drug. This study confirms that the ionic gelation technique is apt for the preparation of metformin nanoparticles with more encapsulation efficacy.

Keywords: Chitosan, Nanoparticles. Metformin, Diabetes, Nano drug delivery system.