Abstract

LEUPROLIDE A GNRH AGONIST A PROMISING TREATMENT OF PROSTATE CANCER

Omkesh R. Gharge*, Chaitali Bornare, Ekta Khapare, Dr. Pankaj Patil, Raju Dhavale, Surbhi Karpe, Ankita Jhadav, Dr. Shailendra Thakare and Dr. Bhushan Suryawanshi

Abstract

Cancer as the leading disease with highest mortality rate it is illustrated by the abnormal growth of cells in an uncontrolled manner due to various external or internal factors. Cancer of the prostate (PCa) which is a type of cancer which only occur in male and frequently in the older populations Prostate cancer is a serious health concern in developed countries. Leuprolide acetate is a synthetic non apeptide analog of GnRH and described chemically as the analog possesses higher potency than the natural hormone. Leuprolide acts by preventing pulsatile hypothalamic stimulation of the adeno-hypophysis, which results in lower gonadotropic hormone release. Androgen deprivation therapy using GnRH agonists is the most common and well reliable treatment for prostate cancer and avoids the stigma associated with Orchiectomy. GnRH agonists have been shown to suppress testosterone levels to

Keywords: prostate cancer, leuproide, Cancer therapy.