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Best Paper Award :
Dr. Dhrubo Jyoti Sen
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Abstract

AN OVERVIEW OF OPTIMAL MANAGEMENT OF CANCER BY COMPUTER AIDED DRUG DESIGN

Latha S. T.*, Dinesh K., Arun Kumar M., Gayathri B., Krishna Kumar P. and Surendra Kumar M.

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Abstract

In the developed world, cancer is the leading cause of death whereas in the developing world it is the second leading causes of death and cancer is the most critical obstacle for the increase of global life expectancy. The design and development of anticancer drugs via traditional drug development has been estimated that around 12 years and 2.7 billion USD, on average. To overcome these demerits in new drug development computer- aided drug discovery/design (CADD) methods have been developed. Computational methods can be utilized to design experiments, and elucidate structure-activity relationships for drug discovery and lead optimization methods. Various approaches of CADD are evaluated as promising techniques according to their need, in between all these structure-based drug design and ligand-based drug design approaches are known as very efficient and powerful techniques in drug discovery and development. The two approaches of drug design ligand based by topoisomerase and structure based by peptide deformylase inhibitors.

Keywords: Anticancer, Computer Aided Drug Design, structure-based drug design, ligand-based drug design, Topoisomerase, peptide deformylase inhibitors.


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