WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :

Download Article: Click Here

Search

Track Your Article

Abstract

COMPARISON OF EFFICACY OF SUBLINGUAL MISOPROSTOL AND INTRACERVICAL DINOPROSTONE GEL FOR INDUCTION OF LABOUR

Dr. Tayyaba Iqbal, Dr. Faiza Ijaz, *Dr. Rabia Wajid and Dr. Mahham Janjua

Abstract

Introduction: World health organization (WHO) defines Induction of Labour as the initiation of labour by artificial means before its spontaneous onset, with the aim of achieving vaginal delivery. Prostaglandins are known agents for induction of labour. Research has proven that intracervical PGE1 is as efficacious as PGE2 except for increased caesarean rate and uterine hyperstimulation. The efficacy of intracervical PGE 2 and sublingual PGE1 needs to be studied more. Objective: To compare sublingual misoprostol versus intracervical dinoprostone gel for induction of labour, in terms of mean Bishop’s score. Patients and Methods: Total of 60 cases fulfilling inclusion criteria were recruited in the study after approval from hospital ethical committee. Data was taken from the Labour Room of Lady Willingdon Hospital after obtaining informed consent. Basic demographic information of all cases was noted. The patients were randomized into two groups. All participants were assessed for Bishop’s score. In group-A females were administered 50 mcg of misoprostol sublingually, and repeat doses of 25 mcg were given in the absence of uterine activity. In group-B, 0.5 mg of PGE2 gel was instilled intracervically and reassessed after 6 h.A second gel of PGE2 was instilled if the Bishop score was less than 4. In both the groups and Bishop’s score more than 5 or less than 5, hospital protocol was followed. Progress and outcome of labour was recorded by the labour room doctor. The data was recorded by the researcher. Results: The mean age all female was 29.52 ± 6.99 years while mean age in Sublingual Misoprostol and Intracervical Dinoprostone Gel group was 29/70 ± 7.7 years and 29.33 ± 6.25 years respectively. The mean gestational age in Sublingual Misoprostol group was 40.63 ± 0.49 weeks and in Intracervical Dinoprostone Gel group was 40.43 ± 0.50 weeks. The mean Bishop’s score in Sublingual Misoprostol group was 8.17 ± 2.83 and in Intracervical Dinoprostone Gel was 5.58 ± 1.80 respectively. The mean Bishop’s score was statistically higher in Sublingual Misoprostol group when compared to Intracervical Dinoprostone Gel, p-value < 0.001. Conclusion: Through the findings of current study we conclude that mean Bishop’s score was statistically higher in Sublingual Misoprostol group in comparison to Intracervical Dinoprostone Gel. Sublingual PGE1 is a better cervical ripening agent, faster and more effective, with a shorter induction-to-delivery interval as compared to intracervical PGE2. So by introducing Sublingual Misoprostol we can reduce the high incidence of cesarean section in local population.

Keywords: Induction of labour, Bishop’s score, Sublingual misoprostol, intracervical dinoprostone gel, C-section.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More