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Abstract

QUALITATIVE PHYTOCHEMICAL STUDY AND EVALUATION OF THE HEALING ACTIVITY OF THE COMBINED CRUDE AQUEOUS EXTRACTS OF TWO ASTERACEAE : CHROMOLAENA ODORATA AND THITONIA DIVERSIFOLIA

Tankeu Severin Elisée*, Fannang Simone Veronique, Bamal Hans Denis, Ngouondjou Foze Teclaire and Etame-Loe Gisele Marie Marguerite

Abstract

The practice of traditional medicine constitutes an important heritage for the African continent. The active ingredients of medicinal plants are used to overcome several pathologies, in particular wounds. The wound corresponds to an interruption of the skin covering. The biological material necessary for this study consisted of plant material, consisting of the leaves of Chromolaena odorata and Tithonia diversifolia and animal material consisting of white wistar rats. The extraction yield was calculated by calculating the ratio of the mass of the extract obtained to the mass of macerated powder. Phytochemical screening was carried out using analytical techniques. The acute toxicity experiment was conducted according to guideline 423 of the OECD protocol. The wound induction technique by excision was used. The respective extraction yields of Chromolaena odorata and Tithonia diversifolia were 6.2% and 1.5%. The tests for alkaloids, anthocyanins, anthraquinones, flavonoids, polyphenols, saponins, steroids, catechin tannins, triterpenes, phenols were positive with the aqueous extracts of the two species except phenols for Chromolaena odorata and catechin tannins for Tithonia diversifolia. The acute toxicity study revealed an LD50 greater than 5000 mg/kg. Four clinical wound parameters were observed during this study. The study of wound healing induced by skin excision was conducted over a period of 18 days. The wounds in the negative control group took the longest (18 days) to heal. Only the combination of extracts administered at a dose of 200 mg/kg was able to heal the wounds in a period of 12 days. The extracts were therefore found to be effective for the treatment of wounds and good for the formulation of healing ointments.

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