WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :

Download Article: Click Here

Search

Track Your Article

Abstract

SOLUBILITY ENHANCEMENT TECHNIQUES: AN OVERVIEW

Himanshi Khatri, Md. Sadique Hussain* and Swati Tyagi

Abstract

Solubility is the process by which a solid dissolve in a liquid phase to form a homogeneous mixture. Solubility is a key characteristic in achieving the necessary amount of medication in blood stream in order for pharmacological effect to be demonstrated. The major problem encountered with formulation is low aqueous solubility of new drug molecule. After oral administration, poorly aqueous soluble drugs require high doses to reach maximum therapeutic plasma concentration. Compounds are classified using the biopharmaceutical classification system (BCS) based on their solubility and permeability. This categorization system has been used by regulatory authorities and health organisations to allow dissolution to be used to prove bioequivalence for highly soluble and highly permeable substances. Drugs with poor aqueous solubility cause slow dissolution rates, generally show low bioavailability when orally administered. The purpose of this review article is for the achievement of effective absorption and improved bioavailability.

Keywords: Bioavailability, Solubility, Nanosuspensions, Dispersion, Supercritical fluid.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More