Abstract

MODIFIED OILS USED IN PREPARATION OF SELFNANOEMULSIFYING DRUG DELIVERY SYSTEM

Namitha Elizabeth Jacob*, Panner Selvam R. and Vineeth Chandy

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Abstract

Self-Nano Emulsifying drug delivery system is a commonly utilized formulation technique in modern technology to improve solubility, especially in hydrophobic drugs. Oils, surfactants, and co-surfactants are the three main ingredients in a self-nano emulsion. Modified oils (hydrogenated oils) and natural oils are the two types of oils utilized in formulation. Because of their fluidity and solubilization capacity, hydrogenated oils are more commonly used in these applications. The particle size for nano-emulsion is between 20-200nm. The different advantages of self-nano emulsifying drug delivery system have been elaborated in the further article like showing better bioavailability, thereby increasing in patient compliance compared to conventional dosage form and hence it can increase the therapeutic efficacy. Oils are the most significant ingredient in the formulation for medication transit in the intestine and to improve adsorption. The main purpose of this review is to focus on the various types of modified oils like short chain, medium chain, long chain. A brief description on the various types of oil such as captex, capyrol, campul along with their chemical structure has been discussed below. The main aim of this article is to gather information about characteristics of various modified or hydrogenated oils that are used in preparation of self-nano emulsifying drugs. Since the characteristics of these oils vary their solubility efficiency will also be different. From this article it is concluded that Modified oils are mainly used for the preparation of self-nano emulsifying drugs as it increases the solubility of the drug thereby improving its stability.

Keywords: Self-nanoemulsifying; Modified oils; Bioavailability; Nano-emulsion.