Abstract

A REVIEW ON THE NOVEL MIND TECHNIQUE FOR TREATING NEURODEGENERATIVE DISORDERS

Samar Saiyed*, Preeti Jadeja and Dr. Rajashree Mashru

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Abstract

The treatment for neurodegenerative disorders is still a challenge due to presence of the blood– brain barrier (BBB) which limits drug penetration and the intricate and complex pathophysiology of brain disorders. However, in the recent times the intranasal route for drug delivery directly to the brain has strategically been manipulated. Intranasal route of transportation can directly deliver the drugs to brain without the need for systemic absorption, thus avoiding the side effects and enhancing the efficacy of the drugs. The intranasal route although quite promising lacks in translational potential. This review describes the Minimally Invasive Nasal Device (MIND) technique, a novel Nasal to Brain (N2B) drug delivery technique which is designed to overcome inherent anatomical and physiological challenges faced by traditional trans-nasal technique and also facilitates more efficient and targeted drug delivery to treat neurodegenerative disorders. This technique has proved to be successful in providing high CNS uptake and brain distribution of blood-brain barrier (BBB) impermeable drugs via direct administration to the olfactory submucosal space in animal model. The MIND technique can easily be carried out on patients in Ear, Nose and Throat (ENT) clinics, and research suggests that there is significant translational potential of this novel, minimally invasive strategy into a reliable therapeutic delivery approach for the treatment of neurodegenerative disorders.

Keywords: CNS drug delivery, Trans-nasal delivery, Neurodegenerative disease, AntagoNAT, Brain Derived Neurotrophic Factor.