Abstract

RESEARCH ON "CARDIOTONIC ACTIVITY OF ETHANOLIC EXTRACT OF CISSUS QUADRANGULARIS LINN."

Sachin P. Nalavade*, Yuvraj L. Pandhare, Sandesh R. Sul and Sourabh D. Thakur

Abstract

The square stemmed variety of Cissus quadrangularis L. variant is a medicinal plant widely used for peptic ulcer and bone fractures in Indian Systems of Medicine. It has also been used to treat osteoporosis, asthma, cough, haemorrhoids and gonorrhoea. The present study is carried out to evaluate the cardiotonic activity. Phytosterol, triterpenes, glycosides, phenols, flavonoids, saponins, tannins and coumarin have been reported to be present in C. quadrangularis. In view of the immense medicinal importance of the plant, this review is an effort to compile all the information reported on its phytochemical and pharmacological activities. The present review is an attempt to generate interest among the masses regarding its immense potential in preventing and treating several common diseases. It contains a rich source of carotenoids, triterpenoids and ascorbic acid. It is given to the frog heart & observe the cardiotonic activity due to the glycoside. Cissus quadrangularis revealed high contents of ascorbic acid, carotene, anabolic steroidal substances, and calcium. The stem contains two asymmetric tetracyclic triterpenoids, and two steroidal principles. The presence of β-sitosterol, δ-amyrin, δ-amyrone, and flavonoids. It was observed that the ethanolic extract of Cissus quadrangularis shows cardiotonic activity.

Keywords: Cardiac glycoside, Digitoxin and C. quadrangularis.