Abstract

A HIGHLY EFFICIENT METHOD OF BIO ACTIVE SYNTHESIS OF 4- (1H-BENZO[D]IMIDAZOLE-2-YL)-N-PHENYLBENZAMIDE ANALOGOUS

A. Bhavani Verma, Y. Pavankumar, B. Priyank and Dr. N. Krishnarao*

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Abstract

The investigation of bioactive synthesis of five 4-(1Hbenzo[ d]imidazole-2-yl)-N-phenylbenzamide(7a-7b) derivatives can be obtained from the compound 4-(1 H-benzo [d] imidazole-2-yl) benzoyl chlorides (5) with substituted aromatic primary amines in the presence of strong base in DCM at reflux. The compound (5) can be obtained by the chlorination of compound (4) with thionyl chloride in dichloromethane as solvent at 100C which is also the compound (4) synthesized by benzil treated with substituted carboxybenzalde and ammonium acetate, acetic acid in the presence of transitionmetal copper acetate catalyst at reflux. All the synthesized compounds were evaluated for their antimicrobial activity. The structures of the newly synthesized compounds were confirmed by FTIR, 1H NMR, 13NMR and MASS spectral data and elemental analysis. The structural determination of desired compounds can be determined by elemental analysis. Compounds were screened for in-vitro antibacterial activity against the representative panel of one gram positive bacterial strains like Staphylococcus aureus and one gram negative bacterial strain like Escherichia coli. Hence, the new derivatives of the titled compounds have been continued to the development for the active potent of new drugs.

Keywords: 4-(1H-benzo[d]imidazole-2-yl)-N-phenylbenzamideanalogous, Benzil, carboxy benzaldehyde, ammonium acetate, copper acetate, antibacterial activity.