WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :

Download Article: Click Here

Search

Track Your Article

Abstract

DESIGN, FORMULATION AND EVALUATION OF HERBAL RECTAL SUPPOSITORIES FOR THE TREATMENT OF COLITIS

Vaishali Potnis*, Komal Navale, Pooja Ghule and Prachi Takbhate

Abstract

Rectal suppositories of ethanolic extract of unripe fruits of Aegle marmelos L. Corr. family Rutaceae were prepared for the treatment of colitis. The medicated rectal suppositories formulations composed of Aegle marmelos Extract (AME): PEG 6000: Softisan 378 and Aegle marmelos Extract: Witepsol W-45. Both placebo and medicated rectal suppositories were characterized for Physical, physicochemical and Organoleptic, dimensions, surface pH, hardness, melting range, liquefaction temperature, liquefaction time, content of drug, dissolution profile (in- vitro). Moreover, the medicated rectal suppositories were characterized for anti-inflammatory efficacy (in-vivo) by using acetic acid induced colitis model. Medicated rectal suppositories possessed good hardness (3 and 4.5 kg/cm2), disintegration time (10-12 and 9-10 min), liquefaction time (10-12 min) and temperature (40-42 and 37-41 0C). Both these formulations also retained >95% AME and demonstrated complete release of contents of AME over a period of 1 h. and remained stable with no gross change in any of the physico-chemical characteristics.

Keywords: Colitis, Anti-inflammatory effect, Medicated Herbal Rectal suppositories.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More