Abstract

DESIGN, FORMULATION AND EVALUATION OF HERBAL RECTAL SUPPOSITORIES FOR THE TREATMENT OF COLITIS

Vaishali Potnis*, Komal Navale, Pooja Ghule and Prachi Takbhate

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Abstract

Rectal suppositories of ethanolic extract of unripe fruits of Aegle marmelos L. Corr. family Rutaceae were prepared for the treatment of colitis. The medicated rectal suppositories formulations composed of Aegle marmelos Extract (AME): PEG 6000: Softisan 378 and Aegle marmelos Extract: Witepsol W-45. Both placebo and medicated rectal suppositories were characterized for Physical, physicochemical and Organoleptic, dimensions, surface pH, hardness, melting range, liquefaction temperature, liquefaction time, content of drug, dissolution profile (in- vitro). Moreover, the medicated rectal suppositories were characterized for anti-inflammatory efficacy (in-vivo) by using acetic acid induced colitis model. Medicated rectal suppositories possessed good hardness (3 and 4.5 kg/cm2), disintegration time (10-12 and 9-10 min), liquefaction time (10-12 min) and temperature (40-42 and 37-41 0C). Both these formulations also retained >95% AME and demonstrated complete release of contents of AME over a period of 1 h. and remained stable with no gross change in any of the physico-chemical characteristics.

Keywords: Colitis, Anti-inflammatory effect, Medicated Herbal Rectal suppositories.