Abstract

COMPARITIVE EVALUATION OF CURCUMIN GEL VERSUS ANTIOXIDANTS FOR TREATMENT OF HOMOGENOUS LEUKOPLAKIA: A CLINICAL STUDY

Dr. Anuradha Pai and *Dr. Sheetal James

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Abstract

Background: Leukoplakia is the most common oral white lesion that is classified under potentially malignant disorder affecting oral mucosa. It is significant as it has a high risk of malignant transformation. There is no single treatment available which is uniformly effective in leukoplakia, it is important to explore a spectrum of therapies to validate a definitive treatment strategy. Aim: To assess the effectiveness of Curcumin gel versus Antioxidants in the treatment of homogenous leukoplakia. Objectives: 1) To assess the effectiveness of Curcumin gel in the treatment of homogenous leukoplakia. 2) To compare the effectiveness of Curcumin gel versus Antioxidants in the treatment of homogenous leukoplakia. Materials and Methods: 30 patients with clinically diagnosed homogenous leukoplakia were recruited for the study and randomly divided into Group 1(Curenext gel group-15) and Group 2 (Antioxidant SM Fibro Capsule group- 15). Group 1 patients were instructed to apply the gel thrice daily for a period of 1 month and Group 2 patients were given SM Fibro Capsule once daily for 1 month. Evaluation of treatment was assessed by quantitative bi-dimensional measurement using clinical photographs of the lesion and measuring the size of the lesion using photoshop software. Results: In both Group 1 and Group 2, marked improvement was observed in size (length and breadth). Mean percentage reduction in lesion length and lesion breadth shows statistically significant improvement result with SM Fibro capsule compared to curenext gel group with p value of

Keywords: Homogenous leukoplakia; Curenext gel; Antioxidant SM Fibro capsule.