Abstract

VALIDATION OF KEELVAYU NIVARANA CHOORANAM FOR ITS ACUTE AND CHRONIC ANTI INFLAMMATORY ACTIVITIES IN ANIMAL MODEL

T. Giftillda Selva Elsee*, M. D. Saravana Devi, K. Rajammadevi Sorubarani and V. Velpandian

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Abstract

To validate Keelvayu Nivarana Chooranam (KVNC) for its acute and chronic anti inflammatory activities in animal model. Acute and Chronic anti inflammatory of KVNC were tested by Carrageenan induced rat paw oedema and Cotton pellet granuloma pouch method respectively. In acute anti inflammatory action of KVNC in doses of 100mg/kg and 200 mg/kg showed 80.13% and 81.33% inhibition of paw edema respectively. In chronic anti inflammatory action of KVNC in doses of 100mg/kg and 200 mg/kg showed 42.86%and 45.24%inhibition of paw edema respectively. From this study, Keelvayu Nivarana Chooranam (KVNC) revealed significant acute and chronic anti inflammatory activities. This result suggests that the study drug could be a drug of choice for treating all inflammatory conditions present in all type of arthritis.

Keywords: Anti inflammatory, Carrageenan, Keelvayu Nivarana Chooranam, Arthritis, Herbal drug.