Abstract

ACRIDONE DERIVATIVES IN REVERSING MULTIDRUG RESISTANCE IN CANCER CELLS – WHERE ARE WE NOW?

*Srikanth Gurralaa, Y.Rajesh Babua, M. Bhagavan Rajua

Abstract

Multi drug resistance (MDR) of cancer cells remains to be an important cause of chemotherapy failure. Search for the new (MDR) reversal agents is still an unceasing challenge for the scientists. Acridone derivatives constitute a class of compounds that are being intensively studied as potential anti cancer drugs. Parent acridone nucleus can be synthesized by a number of methods such as Ullmann condensation, by benzyne mechanism etc. The present study includes brief review about the acridone derivatives such as acridone carboxamide(GF120918), imidazo acridone , bis type acridone andN10-substituted 4-bromo, 4-chloro, 4-fluoro acridones, that have already been shown to be among the group of compounds known to modify P-gp mediated MDR in cancer. The present article also envisages the various modifications of naturally occurring acridone alkaloids that exhibit promising anti cancer activities.

Keywords: acridone, multidrug resistance, acridone alkaloids.