Abstract

ACUTE ORAL TOXICITY OF MADHUMALINI VASANT, ARSHAKUTHAR RASA & SARVATOBHADRA VATI, AN AYURVEDIC HERBO-MINERAL FORMULATIONS IN WISTAR RATS

Chaitali S. Waghmare*, Shivcharan Bidve, R. V. Gudi, Mukesh B. Chawda, Santosh Yadav

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Abstract

Background: Madhumalini Vasant, Arshakuthar Rasa & Sarvatobhadra Vati were used in ethno-medicine to treat various disease. These Ayurvedic formulation contain heavy metals, despite its therapeutic use no studies on its toxicity have been reported. Objective: The aim of the study is to evaluate acute oral toxicity of Madhumalini Vasant, Arshakuthar Rasa & Sarvatobhadra Vati for safety aspect in wistar rats according to OECD TG 423. Material & Method: Female wistar rats were randomly divided into four groups each group contain three rats. Group I served as normal control and remaining three groups receives three Ayurvedic formulations. After dose administration, animals were observed for 14 days for any alterations in clinical signs, behaviour pattern, body weight and mortality. Result: The female wistar rats did not produce any signs & symptoms of treatment related toxicity at high dose of 2000mg/kg. No mortality was observed during 14 days of observation. Conclusion: The data obtained from this study revealed that all the three Ayurvedic formulation is safer at higher dose. It can concluded that the LD50 is greater than 2000mg/kg (LD50 > 2000mg/kg).

Keywords: Ayurveda, Herbo-mineral, toxicity, Madhumalini Vasant, Arshakuthar Rasa, Sarvatobhadra Vati.