Abstract

FORMULATION OF ACYCLOVIR TRANSDERMAL GEL USING ALEOVERA AS PENETRATION ENHANCER FOR HERPES TREATMENT

*Dr. Vivek Gupta and Shobha Rajpoot

Abstract

The aim of this study was to investigate the in-vitro permeation enhancement effects of the gel and Aloe vera using acyclovir as a marker compound. Aloevera, acyclovir and Polysorbate 80 were used for preparation of gel. The perepared grl was evaluated for Determination of pH, Determination of Viscosity, Drug Content, Spreadability and In vitro drug release study. Incorporation of penetration enhancer (polysorbate 80) showed modified or improved in-vitro permeability and enhancement of the drug. In the formulation greatest permeation is achieved at 4 % concentration of penetration enhancer (polysorbate 80) and hence S4 can be termed as the best formulation among those that are developed. In the formulation use of aloe vera gel as absorption base it posses soothing, moisturizing and healing properties, aloe vera gel contain of lignins, that allows for penetrative properties.

Keywords: Aloevera, Acyclovir, Transdermal gel, formulation, Penetration enhancer.